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Heterosynaptic eLTD takes place at synapses adjacent into the stimulated synapses. By way of example, stimulation of Schaffer collaterals in hippocampal CA1 contributes to a persistent reduce in GABAergic inhibition of CA1 pyramidal neurons (106). The mechanism of eLTD at hippocampal inhibitory synapses seems to call for inhibition of adenylyl cycl
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